Tissue specificity of genetic regulation of gene expression

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Gene expression is under partial genetic regulation, which may vary between different cell types and tissues. A new study finds that there is substantial but incomplete overlap among regulatory variants located near the regulated genes in three human tissues.

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Figure 1: Strategy for interpretation of GWAS hits using proxy tissue eQTLs.

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Correspondence to Harald H H Göring.

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Göring, H. Tissue specificity of genetic regulation of gene expression. Nat Genet 44, 1077–1078 (2012) doi:10.1038/ng.2420

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