Exploring the variation within

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We usually think of an individual's cells as sharing the same genome. Challenging this notion, two new studies show that somatic mosaicism is common and can be an early herald of cancer.

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Figure 1: Populations of cells with normal karyotypes, constitutive chromosomal abnormalities or mosaic chromosomal anomalies.

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Correspondence to Steven A McCarroll.

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The authors declare no competing financial interests.

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Macosko, E., McCarroll, S. Exploring the variation within. Nat Genet 44, 614–616 (2012) doi:10.1038/ng.2311

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