Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Traversing the genomic landscape of prostate cancer from diagnosis to death

The clinical spectrum of prostate cancer ranges from curable, local disease to widely metastatic, lethal cancer. Two new prostate cancer genome studies provide the first glimpse at both ends of this spectrum.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Genome-wide alterations in primary and metastatic prostate cancer.


  1. Barbieri, C.E et al. Nat. Genet. 44, 685–689 (2012).

    Article  CAS  Google Scholar 

  2. Grasso, C.S. et al. Nature published online, doi:10.1038/nature11125 (20 May 2012).

  3. Berger, M.F. et al. Nature 470, 214–220 (2011).

    Article  CAS  Google Scholar 

  4. Robbins, C.M. et al. Genome Res. 21, 47–55 (2011).

    Article  CAS  Google Scholar 

  5. Taylor, B.S. et al. Cancer Cell 18, 11–22 (2010).

    Article  CAS  Google Scholar 

  6. Demichelis, F. et al. Genes Chromosom. Cancer 48, 366–380 (2009).

    Article  CAS  Google Scholar 

  7. Cuzick, J. et al. Lancet Oncol. 12, 245–255 (2011).

    Article  CAS  Google Scholar 

  8. Tomlins, S.A. et al. Nature 448, 595–599 (2007).

    Article  CAS  Google Scholar 

  9. Shen, M.M. & Abate-Shen, C. Genes Dev. 24, 1967–2000 (2010).

    Article  CAS  Google Scholar 

  10. Palanisamy, N. et al. Nat. Med. 16, 793–798 (2010).

    Article  CAS  Google Scholar 

  11. Tomlins, S.A. et al. Cancer Cell 13, 519–528 (2008).

    Article  CAS  Google Scholar 

  12. Furukawa, M., He, Y.J., Borchers, C. & Xiong, Y. Nat. Cell Biol. 5, 1001–1007 (2003).

    Article  CAS  Google Scholar 

  13. Cuzick, J. et al. Br. J. Cancer 106, 1095–1099 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Charles L Sawyers.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hieronymus, H., Sawyers, C. Traversing the genomic landscape of prostate cancer from diagnosis to death. Nat Genet 44, 613–614 (2012).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer