Abstract

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 × 10−5 − 5 × 10−7 in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 × 10−8) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-α–induced protein 3 (TNFAIP3).

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Acknowledgements

Funding for this study was provided by the Arthritis Research Campaign (arc). We thank the Wellcome Trust for funding the WTCCC. We would also like to acknowledge the National Health Service (NHS) Research and Development Support Fund for Guy's and St Thomas' and Lewisham NHS Trusts. We acknowledge use of DNA from the British 1958 Birth Cohort collection, funded by the Medical Research Council grant G0000934 and the Wellcome Trust grant 068545/Z/02. IT support was provided by M. Lay, and technical support was provided by P. Gilbert, B. Lad and S.G. Martin. Nursing support was provided by J. Grumley, J. Shotton and C. Farrar.

Author information

Affiliations

  1. Arthritis Research Campaign (arc)–Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK.

    • Wendy Thomson
    • , Anne Barton
    • , Xiayi Ke
    • , Steve Eyre
    • , Anne Hinks
    • , John Bowes
    • , Rachelle Donn
    • , Deborah Symmons
    • , Samantha Hider
    • , Ian N Bruce
    •  & Jane Worthington
  2. School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield S10 2JF, UK.

    • Anthony G Wilson
    •  & Ioanna Marinou
  3. Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Leeds LS7 4SA, UK.

    • Ann Morgan
    •  & Paul Emery
  4. Academic Unit of Molecular Vascular Medicine, the Leeds Institute of Genetics, Health and Therapeutics (LIGHT) Laboratories, Clarendon Way, University of Leeds, Leeds LS2 9JT, UK.

    • Angela Carter
  5. Clinical and Academic Rheumatology, Kings College Hospital National Health Service Foundation Trust, Denmark Hill, London SE5 9RS, UK.

    • Sophia Steer
  6. Bone Research Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK.

    • Lynne Hocking
    •  & David M Reid
  7. University of Oxford Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford OX3 7LD, UK.

    • Paul Wordsworth
    •  & Pille Harrison
  8. Division of Community Health Sciences, St George's, University of London, London SW17 0RE, UK.

    • David Strachan

Consortia

  1. Wellcome Trust Case Control Consortium

    For full lists of members of these consortia, see Supplementary Note

  2. YEAR Consortium

    For full lists of members of these consortia, see Supplementary Note

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Contributions

W.T., A.B., X.K., S.E. and J.W. participated in the conception, design and coordination of the study, data analysis and writing of the manuscript. D.S., S.H., I.N.B., A.G.W., I.M., A.M., P.E., YEAR Consortium, A.C., S.S., L.H., D.M.R., P.W., P.H. and D.S. recruited study subjects and extracted phenotype data. S.E., A.H. and J.B. performed the genotyping. X.K. undertook the statistical analysis. R.D. contributed to preparation of the manuscript. WTCCC provided the initial data for rheumatoid arthritis cases and controls. Members of the WTCCC and YEAR consortium are listed in the Supplementary Note.

Corresponding author

Correspondence to Jane Worthington.

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    Supplementary Text and Figures

    Supplementary Tables 1–5, Supplementary Figure 1, Supplementary Methods, Supplementary Note

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DOI

https://doi.org/10.1038/ng.2007.32

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