Abstract
Non-additive genetic interactions contribute to many genetic disorders, but they are extremely difficult to predict. Here we show that genetic interactions identified in yeast, unlike gene functions or protein interactions, are not highly conserved in animals. Genetic interactions are therefore unlikely to represent simple redundancy between genes or pathways, and genetic interactions from yeast do not directly predict genetic interactions in higher eukaryotes, including humans.
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Acknowledgements
The C. elegans strains used in this work were provided by the C. elegans Genetics Center, USA, and by the National Bioresources Project, Japan. We thank J. Taipale, D. Stemple, M. Isalan, J. Semple and T. Vavouri for comments on the manuscript. We also thank the referees for their comments. J.T. and A.G.F. were funded by the Wellcome Trust. B.L. was supported by the Wellcome Trust, Institutió Catalana de Recerca i Estudis Avançats, and the European Molecular Biology Laboratory-Centre for Genomic Regulation Systems Biology Unit.
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Supplementary Text and Figures
Supplementary Methods, Supplementary Figures 1–3, Supplementary Tables 3, 5 and 6 (PDF 324 kb)
Supplementary table 1
C. elegans orthologs of S. cerevisiae synthetic lethal interactions. (XLS 726 kb)
Supplementary table 2
S. cerevisiae synthetic lethal interactions and their pairwise C. elegans orthologs. (XLS 149 kb)
Supplementary table 4
C. elegans orthologs of S. cerevisiae synthetic lethal interactions with homozygous viable loss-of-function alleles. (XLS 69 kb)
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Tischler, J., Lehner, B. & Fraser, A. Evolutionary plasticity of genetic interaction networks. Nat Genet 40, 390–391 (2008). https://doi.org/10.1038/ng.114
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DOI: https://doi.org/10.1038/ng.114
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