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Dnmt3a silences hematopoietic stem cell self-renewal

DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.

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Figure 1: Proposed direct and indirect mechanisms of action of Dnmt3a during hematopoietic differentiation.


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Correspondence to Jennifer J Trowbridge or Stuart H Orkin.

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Trowbridge, J., Orkin, S. Dnmt3a silences hematopoietic stem cell self-renewal. Nat Genet 44, 13–14 (2012).

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