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Dnmt3a silences hematopoietic stem cell self-renewal

Nature Genetics volume 44, pages 13–14 (2012)Cite this article

DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.

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Figure 1: Proposed direct and indirect mechanisms of action of Dnmt3a during hematopoietic differentiation.

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Authors and Affiliations

  1. Jennifer J. Trowbridge and Stuart H. Orkin are at the Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts, USA.,

    Jennifer J Trowbridge & Stuart H Orkin

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  1. Jennifer J Trowbridge
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  2. Stuart H Orkin
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Correspondence to Jennifer J Trowbridge or Stuart H Orkin.

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The authors declare no competing financial interests.

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Trowbridge, J., Orkin, S. Dnmt3a silences hematopoietic stem cell self-renewal. Nat Genet 44, 13–14 (2012). https://doi.org/10.1038/ng.1043

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