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Fine points in mapping autoimmunity

An efficient way to design genotyping arrays for fine mapping is to group phenotypes with common biology. The first application of the Immunochip to celiac disease provides an insightful view of what this strategy can achieve.

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Figure 1: False-discovery rate (FDR) analysis can guide selection of SNPs for follow-up replication studies.

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Correspondence to Constantin Polychronakos.

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Polychronakos, C. Fine points in mapping autoimmunity. Nat Genet 43, 1173–1174 (2011). https://doi.org/10.1038/ng.1015

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