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Fine points in mapping autoimmunity

Nature Genetics volume 43, pages 1173–1174 (2011)Cite this article

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An efficient way to design genotyping arrays for fine mapping is to group phenotypes with common biology. The first application of the Immunochip to celiac disease provides an insightful view of what this strategy can achieve.

Following the flurry of successful genome-wide association studies (GWAS), complex-trait geneticists have two main priorities. The first is to continue performing GWAS on increasingly larger sample sizes, aiming to detect weaker effects. The second is to discover the functional variant(s) underlying GWAS signals, which requires genotyping associated regions at much higher density. In this issue, Cisca Wijmenga, David van Heel and colleagues1 describe the use of a new approach that addresses both priorities in the study of celiac disease. The innovation, known as the Immunochip2, was designed to maximize the efficiency and reduce the cost of fine mapping autoimmunity risk loci.

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Figure 1: False-discovery rate (FDR) analysis can guide selection of SNPs for follow-up replication studies.

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  1. Constantin Polychronakos is at the Endocrine Genetics Laboratory, Research Institute of the McGill University Health Centre, The Montreal Children's Hospital, Montréal, Québec, Canada.,

    Constantin Polychronakos

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  1. Constantin Polychronakos
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Correspondence to Constantin Polychronakos.

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Polychronakos, C. Fine points in mapping autoimmunity. Nat Genet 43, 1173–1174 (2011). https://doi.org/10.1038/ng.1015

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