Large buildup of strain in the San Andreas fault places region at risk.

References
FialkoY., et al. Nature, 441. 968 - 971 (2006).
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Scripps Institution of Oceanography
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Witze, A. Southern California due major earthquake. Nature (2006). https://doi.org/10.1038/news060619-5
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DOI: https://doi.org/10.1038/news060619-5