Caffeine boosts risk of heart attacks in the genetically susceptible.
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References
CornelisM.C, et al. JAMA, 295. 1135 - 1141 (2006).
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Pearson, H. Coffee mixes badly with certain genes. Nature (2006). https://doi.org/10.1038/news060306-9
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DOI: https://doi.org/10.1038/news060306-9