Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Acetylcholine Noise in Tissue Culture Muscle Cells


ELECTRICAL shot noise fluctuations are produced at the motor endplate by steady streams of acetylcholine (Ach) molecules1–3 and at photoreceptors by steady streams of photons4. These fluctuations appear to be the result of the statistical opening and closing of elementary units of ionic conductance in the excitable cell membrane. Analysis of such shot noise fluctuations gives information about the magnitude of the elementary conductance unit and the kinetics of the activation of these units during membrane excitation.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Katz, B., and Miledi, R., Nature, 226, 962 (1970).

    Article  CAS  Google Scholar 

  2. Katz, B., and Miledi, R., J. Physiol. Lond., 224, 665 (1972).

    Article  CAS  Google Scholar 

  3. Anderson, C. R., and Stevens, C. F., J. Physiol. Lond. (in the press).

  4. Hagins, W. A., Cold Spring Harb. Symp. quant. Biol., 30, 403 (1965).

    Article  CAS  Google Scholar 

  5. Fishbach, G., Nameroff, M., and Nelson, P. G., J. cell. Physiol., 78, 289 (1971).

    Article  Google Scholar 

  6. Fishman, H., Proc. natn. Acad. Sci. U.S.A., 70, 876 (1973).

    Article  CAS  Google Scholar 

  7. Keynes, R. J., Ritchie, J. M., and Rojas, E., J. Physiol. Lond., 213, 235 (1971).

    Article  CAS  Google Scholar 

  8. Ehrenstein, G., Lecar, H., and Nossal, R., J. gen. Physiol., 55, 119 (1970).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

SACHS, F., LECAR, H. Acetylcholine Noise in Tissue Culture Muscle Cells. Nature New Biology 246, 214–216 (1973).

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing