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Membrane Antigens in Arginine-deprived Cultures infected with Marek's Disease Herpesvirus


THE replication of several DNA viruses including Marek's disease herpesvirus (MDHV) is largely dependent on the presence of arginine in the medium1–5 . By using fluorescent antibody (FA) techniques, the membrane or surface antigens induced by several viruses, including poxvirus6–8, polyoma virus9, Epstein-Barr virus10, 11, herpesvirus type 1 (ref. 12), MDHV (refs 13–15) and turkey herpesvirus15, have been found on the surface of cells and seem to be distinct from viral structural antigens (VSA). The characteristics of the membrane antigens (MA) induced by some of these viruses6, 8, 11, 15 except herpesvirus type 1 (ref. 12), were that they appeared on the surface of infected cells as an early product of the viral genome and that DNA inhibitors did not prevent their formation, whereas protein inhibitors did so completely.

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  1. Rouse, H. C., and Schlesinger, R. W., Virology, 33, 513 (1967).

    CAS  Article  Google Scholar 

  2. Winters, A. L., and Consigli, R. A., J. gen. Virol., 10, 53 (1971).

    CAS  Article  Google Scholar 

  3. Goldblum, N., Ravid, Z., and Becker, Y., J. gen. Virol., 3, 143 (1968).

    CAS  Article  Google Scholar 

  4. Tankersley, R. W., jun., J. Bact., 87, 609 (1964).

    CAS  PubMed  Google Scholar 

  5. Mikami, T., Onuma, M., and Hayashi, T. T. A., J. gen. Virol. (in the press).

  6. Ueda, Y., Ito, M., and Tagaya, I., Virology, 38, 180 (1969).

    CAS  Article  Google Scholar 

  7. Miyamoto, H., and Kato, S., Biken J., 11, 343 (1968).

    CAS  PubMed  Google Scholar 

  8. Miyamoto, H., and Kato, S., Biken J., 14, 311 (1971).

    CAS  PubMed  Google Scholar 

  9. Irlin, I. S., Virology, 32, 725 (1967).

    CAS  Article  Google Scholar 

  10. Klein, G., Clifford, P., Klein, E., Smith, R. T., Minowada, J., Kourilsky, F. M., and Burchenal, J. H., J. natn. Cancer Inst., 39, 1027 (1967).

    CAS  Google Scholar 

  11. Gergely, L., Klein, G., and Ernberg, I., Virology, 45, 10 (1971).

    CAS  Article  Google Scholar 

  12. Louery, S. P., Bronson, D. L., and Rawls, W. E., J. gen. Virol., 11, 47 (1971).

    Article  Google Scholar 

  13. Chen, J. H., and Purchase, H. G., Virology, 40, 410 (1970).

    CAS  Article  Google Scholar 

  14. Ahmed, M., and Schidlovsky, G., Cancer Res., 32, 187 (1972).

    CAS  PubMed  Google Scholar 

  15. Ishikawa, T., Naito, M., Osafune, S., and Kato, S., Biken J., 15, 215 (1972).

    CAS  PubMed  Google Scholar 

  16. Onoda, T., Ono, K., Konobe, T., Naito, M., Mori, Y., and Kato, S., Biken J., 13, 219 (1970).

    CAS  PubMed  Google Scholar 

  17. Mikami, T., and Bankowski, R. A., J. natn. Cancer Inst., 45, 319 (1970).

    CAS  Google Scholar 

  18. Pollard, M., and Starr, T. J., Prog. med. Virol., 4, 54 (1962).

    CAS  Google Scholar 

  19. McLimans, W. F., Davis, E. V., Glover, F. L., and Rake, G. W., J. Immun., 79, 428 (1957).

    CAS  PubMed  Google Scholar 

  20. Nazerian, K., and Purchase, H. G., J. Virol., 5, 79 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Naito, M., Ono, K., Tanabe, S., and Kato, S., Biken J., 12, 257 (1969).

    CAS  PubMed  Google Scholar 

  22. Fenner, F. J., and White, D. O., Medical Virology, 299 (Academic Press, New York, 1970).

    Google Scholar 

  23. Roizman, B., Proc. natn. Acad. Sci. U.S.A., 48, 228 (1962).

    CAS  Article  Google Scholar 

  24. Bungay, C., and Watkins, J. F., Br. J. exp. Path., 45, 48 (1964).

    CAS  Google Scholar 

  25. Onuma, M., Mikami, T., and Hayashi, T. T. A., J. natn. Cancer Inst. (in the press).

  26. Ross, L. J. N., Biggs, P. M., and Newton, A. A., J. gen. Virol., 18, 291 (1973).

    CAS  Article  Google Scholar 

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MIKAMI, T., ONUMA, M. & HAYASHI, T. Membrane Antigens in Arginine-deprived Cultures infected with Marek's Disease Herpesvirus. Nature New Biology 246, 211–212 (1973).

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