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Hyperactivity of Remaining Dopaminergic Neurones after Partial Destruction of the Nigro-striatal Dopaminergic System in the Rat

Nature New Biology volume 245, pages 150–151 (1973)Cite this article

Abstract

INJECTION of 6-hydroxydopamine (6-OHDA) in the cell bodies of the substantia nigra of the rat has been found to produce a selective degeneration of the nigro-striatal dopaminergic pathway1. Electron microscopic2 and biochemical3 investigations have determined the specificity and extent of the nigral 6-OHDA induced damage. This model has been used in the present work to study the metabolism of dopamine (DA) in striatal nerve terminals of still undamaged neurones after different partial destructions of the nigro-striatal dopaminergic system.

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Authors and Affiliations

  1. Groupe N B (INSERM U 114), Laboratoire de Biologie Moléculaire, Collège de France 11, place Marcelin Berthelot, Paris, 5°

    YVES AGID, FRANCE JAVOY & JACQUES GLOWINSKI

Authors
  1. YVES AGID
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  2. FRANCE JAVOY
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  3. JACQUES GLOWINSKI
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AGID, Y., JAVOY, F. & GLOWINSKI, J. Hyperactivity of Remaining Dopaminergic Neurones after Partial Destruction of the Nigro-striatal Dopaminergic System in the Rat. Nature New Biology 245, 150–151 (1973). https://doi.org/10.1038/newbio245150a0

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