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Effects of Low-dose X Irradiation on the Chromosomal Non-disjunction in Aged Mice

Nature New Biology volume 244, pages 206–208 (1973)Cite this article

Abstract

IT is well known that an increased incidence of Down's syndrome and of some other chromosome anomalies is associated with advancing maternal age. Several assumptions have been tested in an effort to determine the essential factor predisposing to non-disjunction with increasing age of the mother. Henderson and Edwards1 reported that a decrease in the frequency of chiasmata and an increase in the frequency of univalents are associated with an increase of maternal age. Deficiency of chiasmata seems to be responsible for Down's syndrome.

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Authors and Affiliations

  1. Department of Hygiene and Preventive Medicine, Niigata University School of Medicine, Niigata City

    MASAHARU YAMAMOTO, TAKAMICHI SHIMADA, AKIRA ENDO & GEN-ICHI WATANABE

Authors
  1. MASAHARU YAMAMOTO
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  2. TAKAMICHI SHIMADA
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  3. AKIRA ENDO
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  4. GEN-ICHI WATANABE
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YAMAMOTO, M., SHIMADA, T., ENDO, A. et al. Effects of Low-dose X Irradiation on the Chromosomal Non-disjunction in Aged Mice. Nature New Biology 244, 206–208 (1973). https://doi.org/10.1038/newbio244206a0

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  • DOI: https://doi.org/10.1038/newbio244206a0

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