Abstract
BALL1 has recently reconsidered the question whether degenerate code words are chosen on the basis of their ability to optimize secondary structure. Early evidence by Adams et al.2, who sequenced a hairpin of the phage R17 coat protein gene, suggested that third letters of degenerate codons might be selected on the basis of their possible involvement in base pairing.
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References
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FIERS, W. The Choice of Code Words in Phage MS2 RNA. Nature New Biology 244, 186 (1973). https://doi.org/10.1038/newbio244186a0
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DOI: https://doi.org/10.1038/newbio244186a0