Abstract
BOTH cell-mediated immunity (CMI) and helper activity in antibody synthesis are functions generally ascribed to thymus-derived lymphocytes (T cells)1–3. The T cells involved in CMI and antibody synthesis towards the same antigen may be the same cells: they may be derived from a common precursor but along different pathways or stages of differentiation, or they may belong to distinct subpopulations of T lymphocytes. We have investigated these three possibilities by inducing CMI in vivo without eliciting antibody formation, and assessing the effect of this state of sensitization on helper activity against the same antigen in vitro.
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GORDON, J., YU, H. Relationship of T Cells involved in Cell-mediated Immunity and Antibody Synthesis. Nature New Biology 244, 21–22 (1973). https://doi.org/10.1038/newbio244021a0
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DOI: https://doi.org/10.1038/newbio244021a0
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