Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Isolation, Purification and Structure of Aleutian Disease Virus by Immunological Techniques

Nature New Biology volume 243, pages 174–176 (1973)Cite this article

Abstract

Aleutian disease (AD) of mink is an immunological disease, and the immune response against the viral antigen initiates the pathological changes1–3. This “slow virus”, however, replicates as rapidly as do many viruses which cause acute disease4,5. The disease is characterized by the development of hypergammaglobulinaemia, systemic proliferation of plasma cells, glomerulonephritis, and hepatitis, and is invariably fatal6–10. Extremely high titres of antibody have been detected from serum of hypergammaglobulinaemic mink3,5,11–13. The role of the host immune response in causing the disease condition has been shown by the prevention of lesions by immunosuppression1 and by the enhancement of lesions following the administration of a killed virus vaccine or passive antibody2.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Cheema, A., Henson, J. B., and Gorham, J. R., Amer. J. Pathol., 66, 543 (1972).

    CAS  Google Scholar 

  2. Porter, D. D., Larsen, A. E., and Porter, H. C., J. Immunol., 109, 1 (1972).

    CAS  PubMed  Google Scholar 

  3. Cho, H. J., and Ingram, D. G., Canad. J. Comp. Med., 37 (in the press).

  4. Eklund, C. M., Hadlow, W. J., Kennedy, R. C., Boyle, C. C., and Jackson, T. A., J. Infect. Dis., 118, 510 (1968).

    Article  CAS  Google Scholar 

  5. Porter, D. D., Larsen, A. E., and Porter, H. C., J. Exp. Med., 130, 575 (1969).

    Article  CAS  Google Scholar 

  6. Obel, A. L., Amer. J. Vet. Res., 20, 384 (1959).

    Google Scholar 

  7. Helmboldt, C. F., and Jungherr, E. L., Amer. J. Vet. Res., 19, 212 (1958).

    CAS  PubMed  Google Scholar 

  8. Henson, J. B., Leader, R. W., and Gorham, J. R., Proc. Soc., Exp. Biol Med., 107, 919 (1961).

    Article  CAS  Google Scholar 

  9. Karstad, L., Canad. J. Comp. Med., 29, 66 (1965).

    CAS  PubMed  Google Scholar 

  10. Henson, J. B., Leader, R. W., Gorham, J. R., and Padgett, G. A., Pathol. Vet., 3, 289 (1966).

    CAS  PubMed  Google Scholar 

  11. McGuirre, T. C., Crawford, T. B., and Henson, J. B., J. Immunol., 107, 1481 (1971).

    Google Scholar 

  12. Cho, H. J., and Ingram, D. G., Proc. Canad. Fed. Biol. Soc., 15, 299 (1972).

    Google Scholar 

  13. Cho, H. J., and Ingram, D. G., Fur Trade J., 50 (8), 6 (1972).

    Google Scholar 

  14. Buko, L., and Kenyon, A. J., Nature, 216, 69 (1967).

    Article  CAS  Google Scholar 

  15. Tabel, H., and Ingram, D. G., Arch. Virusforsch., 32, 53 (1970).

    Article  CAS  Google Scholar 

  16. Tsai, K. S., Grinyer, I., Pan, I. C., and Karstad, L., Canad. J. Microbiol., 15, 138 (1969).

    Article  CAS  Google Scholar 

  17. Cho, H. J., and Ingram, D. G., J. Immunol., 108, 555 (1972).

    CAS  PubMed  Google Scholar 

  18. Basrur, P. K., and Karstad, L., Canad. J. Comp. Med., 30, 295 (1966).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Veterinary Microbiology and Immunology, Ontario Veterinary College, University of Guelph, Guelph, Ontario

    H. J. CHO & D. G. INGRAM

Authors
  1. H. J. CHO
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. G. INGRAM
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

CHO, H., INGRAM, D. Isolation, Purification and Structure of Aleutian Disease Virus by Immunological Techniques. Nature New Biology 243, 174–176 (1973). https://doi.org/10.1038/newbio243174a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio243174a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing