Abstract
Replication of influenza viruses, but not parainfluenza viruses, is sensitive in the early stages to treatment of host cells with actinomycin D and other inhibitors of DNA-dependent RNA synthesis1. Recent evidence suggests that the influenza viruses require host cellular DNA transcription mediated by DNA-dependent RNA polymerase II (nucleo-plasmic) early in the replicative cycle, and this is why they are sensitive to inhibitors of DNA function2. The inability of influenza viruses to grow in cells where DNA-dependent RNA synthesis has been suppressed has seriously hampered studies of the early events in virus RNA synthesis.
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MAHY, B., COX, N., ARMSTRONG, S. et al. Multiplication of Influenza Virus in the Presence of Cordycepin, an Inhibitor of Cellular RNA Synthesis. Nature New Biology 243, 172–174 (1973). https://doi.org/10.1038/newbio243172a0
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DOI: https://doi.org/10.1038/newbio243172a0
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