Abstract
A pure initiation factor from ascites tumour cells is necessary for protein synthesis directed by EMC RNA but not by globin mRNA. Mammalian initiation factors can therefore distinguish between different messengers.
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References
Revel, M., Aviv, N., Groner, Y., and Pollock, Y., FEBS Lett., 9. 213 (1970).
Berissi, H., Groner, Y., and Revel, M., Nature New Biology, 234, 44 (1971).
Lee-Huang, S., and Ochoa, S., Nature New Biology, 234, 236 (1971).
Prichard, P. M., Gilbert, J. M., Shafritz, D. A., and Anderson, W. F., Nature, 226, 511 (1970).
Crystal, R. G., Shafritz, D. A., Prichard, P. M., and Anderson, W. F., Proc. US Nat. Acad. Sci., 68, 1810 (1971).
Prichard, P. M., Picciano, D. J., Laycock, D. G., and Anderson, W. F., Proc. US Nat. Acad. Sci., 68, 2752 (1971).
Heywood, S. M., Proc. US Nat. Acad. Sci., 67, 1782 (1970); Rourke, A. W., and Heywood, S. M., Biochemistry, 11, 2061 (1972).
Stavnezer, J., and Huang, R. C. C., Nature New Biology, 230, 172 (1971).
Lockard, R. E., and Lingrel, J. B., Nature New Biology, 233, 204 (1971).
Mathews, M. B., Osborn, M., and Lingrel, J. B., Nature New Biology, 233, 206 (1971).
Rhoads, R. E., McKnight, G. S., and Schimke, R. T., J. Biol. Chem., 246, 7404 (1971).
Pemberton, R. E., Housman, D., Lodish, H., and Baglioni, C., Nature New Biology, 235, 99 (1972).
Mathews, M. B., Osborn, M., Burns, A. J. M., and Bloemendal, H., Nature New Biology, 236, 5 (1972).
Gurdon, J. B., Lane, C. D., Woodland, H. R., and Marbaix, G., Nature, 233, 177 (1971).
Smith, A. E., FEBS Symposium, 23, 255 (1972).
Smith, A. E., Eur. J. Biochem., 33, 301 (1973).
Wigle, D. T., Eur. J. Biochem. (in the press).
Monro, R. E., Celma, M. L., and Vasquez, D., Nature, 222, 356 (1969).
Smith, A. E., Marcker, K. A., and Mathews, M. B., Nature, 225, 184 (1970).
Metafora, S., Terada, M., Dow, L. W., Marks, P. A., and Bank, A., Proc. US Nat. Acad. Sci., 69, 1299 (1972).
Mathews, M. B., Nature, 228, 661 (1970).
Wahba, A. J., Chae, Y. B., Iwasaki, K., Mazumder, R., Miller, M. J., Sabol, S., and Sillero, M. A. G., Cold Spring Harbor Symp. Quant. Biol., 34, 285 (1969).
Leader, D. P., Klein-Bremhaar, H., Wool, I. G., and Fox, A., Biochem. Biophys. Res. Commun., 46, 215 (1972).
Zasloff, M., and Ochoa, S., Proc. US Nat. Acad. Sci., 68, 3059 (1971).
Grummt, F., Abstr. Commun. Seventh Meet. Eur. Biochem. Soc., 171 (1971).
Mathews, M., and Korner, A., Eur. J. Biochem., 17, 328 (1970).
Weber, K., and Osborn, M., J. Biol. Chem., 244, 4406 (1969).
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WIGLE, D., SMITH, A. Specificity in Initiation of Protein Synthesis in a Fractionated Mammalian Cell-free System. Nature New Biology 242, 136–140 (1973). https://doi.org/10.1038/newbio242136a0
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DOI: https://doi.org/10.1038/newbio242136a0
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