Abstract
Complexes of 70S RNA and reverse transcriptase have been identified in the white blood cells of 95% of leukaemic patients examined. The DNA synthesized by these complexes hybridizes to the RNA of the Rauscher leukaemia virus. It does not anneal to the RNA of either the avian myeloblastosis virus or of the mouse mammary tumour virus.
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References
Axel, R., Schlom, J., and Spiegelman, S., Proc. US Nat. Acad. Sci., 69, 535 (1972).
Axel, R., Schlom, J., and Spiegelman, S., Nature, 235, 32 (1972).
Hehlmann, R., Kufe, D., and Spiegelman, S., Proc. US Nat. Acad. Sci., 69, 435 (1972).
Kufe, D., Hehlmann, R., and Spiegelman, S., Science, 175, 182 (1972).
Hehlmann, R., Kufe, D., and Spiegelman, S., Proc. US Nat. Acad. Sci., 69, 1727 (1972).
Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970).
Baltimore, D., Nature, 226, 1209 (1970).
Schlom, J., and Spiegelman, S., Science, 174, 840 (1971).
Schlom, J., Spiegelman, S., and Moore, D., Science, 175, 542 (1972).
Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 227, 563 (1970).
Rokutanda, M., Rokutanda, H., Green, M., Fujinaga, K., Ray, R. U., and Gurgo, C., Nature, 227, 1026 (1970).
Bishop, D. H. L., Ruprecht, R., Simpson, R. W., and Spiegelman, S., J. Virol., 8, 730 (1971).
Gulati, S. C., Axel, R., and Spiegelman, S., Proc. US Nat. Acad. Sci., 69, 2020 (1972).
Manly, K. F., Smoler, D. F., Bromfield, E., and Baltimore, D., J. Virol., 7, 106 (1971).
Varmus, H. E., Levinson, W. E., and Bishop, J. M., Nature New Biology, 223, 19 (1971).
Gillespie, D., Marshall, S., and Gallo, R. C., Nature, 236, 227 (1972).
Green, M., and Cartas, M., Proc. US Nat. Acad. Sci., 69, 791 (1972).
Lai, M. M. C., and Duesberg, P. H., Nature, 235, 383 (1972).
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BAXT, W., HEHLMANN, R. & SPIEGELMAN, S. Human Leukaemic Cells contain Reverse Transcriptase associated with a High Molecular Weight Virus-related RNA. Nature New Biology 240, 72–75 (1972). https://doi.org/10.1038/newbio240072a0
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DOI: https://doi.org/10.1038/newbio240072a0
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