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E. coli DNA Polymerase I and other Host Functions participate in T4 DNA Replication and Recombination

Nature New Biology volume 240, pages 12–16 (1972)Cite this article

Abstract

The recognition of bacterial functions involved in DNA metabolism of bacteriophage T4 might reveal interactions between different enzymes during DNA replication and recombination. To detect such functions we have studied the replication of complete and incomplete T4 chromosomes in various mutant strains of Escherichia coli that are defective in their own DNA metabolism. We found that several E. coli functions can substitute for phage functions in T4 replication and recombination, and will discuss here the role of the E. coli pol A gene which codes for DNA polymerase I1–4 and of the dna B and E genes3,5.

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Authors and Affiliations

  1. Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee, 37235

    GISELA MOSIG, DONALD W. BOWDEN & SUSAN BOCK

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  1. GISELA MOSIG
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  2. DONALD W. BOWDEN
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  3. SUSAN BOCK
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MOSIG, G., BOWDEN, D. & BOCK, S. E. coli DNA Polymerase I and other Host Functions participate in T4 DNA Replication and Recombination. Nature New Biology 240, 12–16 (1972). https://doi.org/10.1038/newbio240012a0

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  • DOI: https://doi.org/10.1038/newbio240012a0

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