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Synthesis of Mouse Haemoglobin and Globin mRNA in Leukaemic Cell Cultures

Abstract

FRIEND virus infected leukaemic spleen cells, if maintained under tissue culture conditions, differentiate into erythroblasts that incorporate iron and synthesize haem1,2. Addition of dimethyl sulphoxide (DMSO) to these tissue culture cells stimulates their differentiation along the erythrocytic line much further and results in an increased production of haemoglobin3.

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OSTERTAG, W., MELDERIS, H., STEINHEIDER, G. et al. Synthesis of Mouse Haemoglobin and Globin mRNA in Leukaemic Cell Cultures. Nature New Biology 239, 231–234 (1972). https://doi.org/10.1038/newbio239231a0

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