Abstract
DURING development of T4 phage in E. coli, control at the translational level may play an important part in switching the reading of early to late T4 messenger RNAs. In vitro experiments have shown that protein factors isolated from ribosomes of T4 infected cells can restrict translation of either host mRNA or R17 phage RNA, whilst permitting normal translation of late T4 mRNA1–4. This alteration of specificity has been attributed to an initiation factor F35,6. It is unlikely that this switch is related to the shut-off of host protein synthesis which occurs immediately after infection7,8, because they occur at distinctly different times in vivo1, 3.
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YOSHIDA, M. Lack of Discrimination between Early and Late T4 mRNA by Host Initiation Factors. Nature New Biology 239, 178–180 (1972). https://doi.org/10.1038/newbio239178a0
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DOI: https://doi.org/10.1038/newbio239178a0