INVESTIGATION of a tumour system requires a ready supply of tissue and ability to manipulate the growing environment. In vivo methods of maintenance are preferred, because the tissue is morphologically similar to the original, the therapeutic: toxicity ratio of possible treatments can be assessed and agents affecting tumour growth indirectly by changing the internal milieu may be studied. However, viability after transplantation to privileged sites and to immature2 and conventionally immunosuppressed recipients3 has been unreliable. We report here experiments in which human tumour tissues have been maintained in mice1 deficient in cell-mediated immunity.
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Immunological recovery of thymectomized and sham-thymectomized lethally irradiated mice reconstituted with syngeneic hone marrow cells
Nature New Biology (1973)