Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Human Tumours grown in Mice


INVESTIGATION of a tumour system requires a ready supply of tissue and ability to manipulate the growing environment. In vivo methods of maintenance are preferred, because the tissue is morphologically similar to the original, the therapeutic: toxicity ratio of possible treatments can be assessed and agents affecting tumour growth indirectly by changing the internal milieu may be studied. However, viability after transplantation to privileged sites and to immature2 and conventionally immunosuppressed recipients3 has been unreliable. We report here experiments in which human tumour tissues have been maintained in mice1 deficient in cell-mediated immunity.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Patterson, W. B., & Patterson, H. B., Transplant. Bull., 3, 56 (1956).

    Google Scholar 

  2. 2

    Southam, C. M., Tanzi, A. F., & Ross, S. C., Cancer, 19, 1670 (1966).

    CAS  Article  Google Scholar 

  3. 3

    Toolan, H. W., Proc. NY Soc. Exp. Biol., 77, 572 (1951).

    CAS  Article  Google Scholar 

  4. 4

    Davies, A. J. S., et al., Immunology, 17, 111 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

CASTRO, J. Human Tumours grown in Mice. Nature New Biology 239, 83–84 (1972).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing