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Chemical Carcinogenesis in Mice inhibited by Interferon

Nature New Biology volume 239, pages 31–32 (1972)Cite this article

Abstract

SEVERAL experiments have demonstrated that the anti-viral substance, interferon, can inhibit the growth of spontaneous1,2, transplanted3 and virus-induced neoplasms in mice4–7. Lieberman et al.5 reported that interferon treatment partially suppressed X-radiation-induced leukaemia in C57B1/6 mice. As they pointed out, the inhibitory effect provided additional evidence for the theory that X-rays cause lymphoma through the activation of a leukaemogenic type C RNA viral intermediate. In this communication, we report studies with CF-1 mice (Carworth Farms, New York City) to determine the effects of interferon on SC tumour induction by 3-methylcholanthrene (3-MC). These mice were previously shown to harbour high levels of type C RNA gs antigen and.infectious virus in normal spleens and in induced tumours, while spontaneous tumours rarely develop until late in life8–10.

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Authors and Affiliations

  1. Department of Viral-Chemical Oncology, Microbiological Associates, Inc., 4733 Bethesda Avenue, Bethesda, Maryland, 20014

    RONALD A. SALERNO, CARRIE E. WHITMIRE & IVETTE M. GARCIA

  2. Viral Carcinogenesis Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014

    ROBERT J. HUEBNER

Authors
  1. RONALD A. SALERNO
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  2. CARRIE E. WHITMIRE
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  3. IVETTE M. GARCIA
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  4. ROBERT J. HUEBNER
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SALERNO, R., WHITMIRE, C., GARCIA, I. et al. Chemical Carcinogenesis in Mice inhibited by Interferon. Nature New Biology 239, 31–32 (1972). https://doi.org/10.1038/newbio239031a0

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