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Nuclear DHT-Receptor in Tfm/Y Kidney Cell

Nature New Biology volume 238, pages 216–217 (1972)Cite this article

Abstract

OUR previous studies on the X-linked testicular feminization (Tfm) mutation1 of the mouse2–4 showed that the so-called cytosol and nuclear 5αx-dihydrotestosterone (DHT) receptor protein5–7 might be a regulatory protein specified by the Tfm locus. The dual role of being a translational repressor in the cytoplasma and a mediator of hypertrophy in the nucleus was envisaged8. We found, however, another class of androgen-receptor in the polysome fraction of kidney proximal tubule cells which seems better qualified to be a translational regulator. Since a single gene locus specifies only one kind of polypeptide chain, we re-examined whether the cytosol and nuclear DHT-receptor protein underwent a true mutational change in Tfm/Y individuals.

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Authors and Affiliations

  1. Department of Biology, City of Hope Medical Center, Duarte, California

    ULRICH DREWS, HIDEYO ITAKURA, RYUICHI DOFUKU, ULRICH TETTENBORN & SUSUMU OHNO

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  1. ULRICH DREWS
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  2. HIDEYO ITAKURA
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  3. RYUICHI DOFUKU
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  4. ULRICH TETTENBORN
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  5. SUSUMU OHNO
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DREWS, U., ITAKURA, H., DOFUKU, R. et al. Nuclear DHT-Receptor in Tfm/Y Kidney Cell. Nature New Biology 238, 216–217 (1972). https://doi.org/10.1038/newbio238216a0

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