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A Role of Cyclic AMP in a Neurotrophic Process

Nature New Biology volume 238, pages 154–155 (1972)Cite this article

Abstract

TROPHIC effects of neurones can be defined as long-term interactions between nerve cells and the tissues they innervate, which initiate or control molecular modifications in the target cells1. An example of trophic activity is the maintenance of the motor end plate of skeletal muscle by the nerve fibre. The motor nerve appears to exert a morphogenetic effect on its formation, because both the structural specializations and Cholinesterase activity of the end plate develop only in relation to the nerve fibre2–5. Conversely, denervation is followed usually by degeneration of the junction and loss of end plate Cholinesterase activity6–8.

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  1. Department of Anatomy, Yale University School of Medicine, New Haven, Connecticut, 06510

    THOMAS L. LENTZ

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  1. THOMAS L. LENTZ
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LENTZ, T. A Role of Cyclic AMP in a Neurotrophic Process. Nature New Biology 238, 154–155 (1972). https://doi.org/10.1038/newbio238154a0

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  • DOI: https://doi.org/10.1038/newbio238154a0

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