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Is 1-Hydroxy-3-aminopyrrolidone-2 (HA-966) a Selective Excitatory Amino-acid Antagonist?

Nature New Biology volume 238, pages 61–63 (1972)Cite this article

Abstract

AFTER the discovery of the excitatory effects of glutamate and aspartate on single neurones of the mammalian central nervous system1, the possibility that these substances might act as central excitatory transmitter substances has continued to gain support. Compelling evidence either for or against this hypothesis would, however, require the use of specific pharmacological antagonists, and unfortunately there has been only limited success in the search for antagonists of either the excitant amino-acid action or of synaptically-evoked excitation in the CNS2.

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References

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Authors and Affiliations

  1. Department of Pharmacology, School of Pharmacy, Brunswick Square, London, W1 MRC

    J. DAVIES & J. C. WATKINS

  2. Neuropsychiatry Unit, Woodmansterne Road, Carshalton, Surrey

    J. DAVIES & J. C. WATKINS

Authors
  1. J. DAVIES
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  2. J. C. WATKINS
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DAVIES, J., WATKINS, J. Is 1-Hydroxy-3-aminopyrrolidone-2 (HA-966) a Selective Excitatory Amino-acid Antagonist?. Nature New Biology 238, 61–63 (1972). https://doi.org/10.1038/newbio238061a0

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