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Hormone Action and the Levels of Cyclic AMP and Prostaglandins in the Toad Bladder

Nature New Biology volume 238, pages 27–31 (1972)Cite this article

Abstract

THERE is overwhelming evidence to connect cyclic 3′,5′-adenos-ine monophosphate (cyclic AMP) with hormone action in various tissues1. For example, the toad bladder responds to neurohypophyseal hormones (ADH) with an increase in water permeability2 and with an increase in the mucosal to serosal transport of sodium3. ADH also causes an increase in cyclic AMP levels in the tissue4 and the actions of the hormone can be mimicked by addition of the cyclic nucleotide2,5. Orloff and Handler5 have suggested that cyclic AMP directly affects the permeability of the mucosal face of the epithelial cells to water and to sodium, and that there are two separate adenyl cyclase systems responsible for controlling the permeability to water and to sodium6,7.

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Authors and Affiliations

  1. University Department of Pharmacology, Cambridge

    P. Y. D. WONG, J. R. BEDWANI & A. W. CUTHBERT

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  1. P. Y. D. WONG
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  3. A. W. CUTHBERT
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WONG, P., BEDWANI, J. & CUTHBERT, A. Hormone Action and the Levels of Cyclic AMP and Prostaglandins in the Toad Bladder. Nature New Biology 238, 27–31 (1972). https://doi.org/10.1038/newbio238027a0

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