Abstract
SEVERAL investigators have speculated that the basis for all cellular contractile activity resides in a common molecular mechanism involving an interaction between actin and myosin1–4. Thin filaments resembling the actin filaments of muscle have indeed been widely observed3–5 and the recent demonstrations of heavy meromyosin binding to thin filaments4–6 suggest that these ubiquitous filaments are, in fact, actin. Although muscle-like thick filaments have not been observed in non-muscle cells, myosin thick filaments have been reconstituted from blood platelet preparations1. To our knowledge, however, no one has presented evidence for the natural occurrence of ordered arrays of thick and thin filaments in non-muscle cells.
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RASH, J., McDONALD, T., SACHS, H. et al. Muscle-like Arrays in a Fibroblast Line. Nature New Biology 237, 160 (1972). https://doi.org/10.1038/newbio237160a0
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DOI: https://doi.org/10.1038/newbio237160a0
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