Abstract
IT is generally accepted that botulinum toxin entirely blocks transmitter release from motor nerve terminals without affecting nerve conduction or the sensitivity of the muscle membrane to acetylcholine. In particular, it has been reported that with both acute and chronic intoxication with type A botulinum, miniature end-plate potentials (m.e.p.p.s.) disappear completely from a muscle at about the time that transmission is blocked1,2. The action of botulinum toxin has been reinvestigated following acute application of toxin to the rat diaphragm in vitro, and chronic paralysis of rat soleus muscle following a single intramuscular injection of toxin; miniature potentials have been observed to persist following blockade of neuromuscular transmission.
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SPITZER, N. Miniature End-plate Potentials at Mammalian Neuromuscular Junctions Poisoned by Botulinum Toxin. Nature New Biology 237, 26–27 (1972). https://doi.org/10.1038/newbio237026a0
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DOI: https://doi.org/10.1038/newbio237026a0
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