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Quinacrine Fluorescence Patterns and Terminal DNA Labelling of Human C Group Chromosomes

Nature New Biology volume 236, pages 76–78 (1972)Cite this article

Abstract

THE human C group chromosomes have been difficult to study because they have rather similar morphology. Application of the quinacrine fluorescent staining technique developed by Caspersson et al.1 now allows the identification of individual chromosomes and of the chromosome segments involved in translocations because the fluorescent patterns are not altered by the translocation2–4. We have reported the value of this technique in analysing abnormalities of the D4 and G3 groups. We report here a variety of structural changes of C group chromosomes which have been characterized in this way, as well as the terminal DNA replication pattern of the C group chromosomes.

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References

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Authors and Affiliations

  1. Southbury Training School, Southbury, Connecticut, 06488

    W. R. BREG

  2. Division of Medical Genetics, Department of Pediatrics, School of Medicine, Yale University, New Haven, Connecticut, 06510

    W. R. BREG

  3. Departments of Human Genetics and Development and of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, 10032

    P. W. ALLDERDICE, D. A. MILLER & O. J. MILLER

Authors
  1. W. R. BREG
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  2. P. W. ALLDERDICE
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  3. D. A. MILLER
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  4. O. J. MILLER
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BREG, W., ALLDERDICE, P., MILLER, D. et al. Quinacrine Fluorescence Patterns and Terminal DNA Labelling of Human C Group Chromosomes. Nature New Biology 236, 76–78 (1972). https://doi.org/10.1038/newbio236076a0

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