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Morphological Differentiation induced by Prostaglandin in Mouse Neuroblastoma Cells in Culture


PROSTAGLANDIN is known to affect concentrations of cyclic AMP in some cells1. Dibutyryl cyclic AMP induces irreversible differentiation of mouse neuroblastoma cells in vitro2, which raises the question of whether prostaglandin would mimic this effect. I report here that prostaglandins (PG)E1 and PGE2 induce irreversible morphological differentiation of mouse neuroblastoma cells in culture as shown by axon formation, whereas PGF2α does not.

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PRASAD, K. Morphological Differentiation induced by Prostaglandin in Mouse Neuroblastoma Cells in Culture. Nature New Biology 236, 49–52 (1972).

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