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Morphological Differentiation induced by Prostaglandin in Mouse Neuroblastoma Cells in Culture

Nature New Biology volume 236, pages 49–52 (1972)Cite this article

Abstract

PROSTAGLANDIN is known to affect concentrations of cyclic AMP in some cells1. Dibutyryl cyclic AMP induces irreversible differentiation of mouse neuroblastoma cells in vitro2, which raises the question of whether prostaglandin would mimic this effect. I report here that prostaglandins (PG)E1 and PGE2 induce irreversible morphological differentiation of mouse neuroblastoma cells in culture as shown by axon formation, whereas PGF2α does not.

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Authors and Affiliations

  1. Department of Radiology, University of Colorado Medical Center, 4200 East Ninth Avenue, Denver, Colorado, 80220

    KEDAR N. PRASAD

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  1. KEDAR N. PRASAD
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PRASAD, K. Morphological Differentiation induced by Prostaglandin in Mouse Neuroblastoma Cells in Culture. Nature New Biology 236, 49–52 (1972). https://doi.org/10.1038/newbio236049a0

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  • DOI: https://doi.org/10.1038/newbio236049a0

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