Abstract
DAUNOMYCIN1–3, a glycosidic anthracycline antibiotic from Streptomyces peucetius4, is being used in the treatment of acute leukaemia and solid tumours in man5,6. The biological activity seems to be due to complex formation with the DNA of deoxyribonucleoprotein4. In vivo, daunomycin inhibits both RNA and DNA synthesis7,8 and, in vitro, DNA-dependent RNA polymerase and DNA polymerase7–9.
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PIGRAM, W., FULLER, W. & HAMILTON, L. Stereochemistry of Intercalation: Interaction of Daunomycin with DNA. Nature New Biology 235, 17–19 (1972). https://doi.org/10.1038/newbio235017a0
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DOI: https://doi.org/10.1038/newbio235017a0
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