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Differential Response of B and T Cells to ALS revealed by Electrophoretic Mobility Determinations

Nature New Biology volume 234, pages 86–87 (1971)Cite this article

Abstract

SINCE their discovery anti-lymphocyte antisera (ALS) have been widely investigated in order to clarify their mode of action and to determine their usefulness in clinical practice. Briefly, it seems that the efficacy of a particular ALS depends on its mode of production and on the method adopted for testing its immunosuppressive effect. It also seems likely that many ALS have a harmful effect on a population of thymus-dependent (T) lymphocytes1. It is the intention of this paper to confirm this notion and to indicate that other lymphocytes (B cells) are likely to be less affected by ALS.

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Author notes

  1. G. BERT

    Present address: Istituto di Patologia Speciale Medica e Meto-dologia Clinica dell'Universita' di Torino, Via Genova 3, 10126, Torino, Italy

Authors and Affiliations

  1. Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, Fulham Road, London, SW3 6JB

    G. BERT, J. A. FORRESTER & A. J. S. DAVIES

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  1. G. BERT
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  2. J. A. FORRESTER
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  3. A. J. S. DAVIES
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BERT, G., FORRESTER, J. & DAVIES, A. Differential Response of B and T Cells to ALS revealed by Electrophoretic Mobility Determinations. Nature New Biology 234, 86–87 (1971). https://doi.org/10.1038/newbio234086a0

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  • DOI: https://doi.org/10.1038/newbio234086a0

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