Abstract
MAN-MOUSE somatic cell hybrids are useful for the study of genetic linkage in man because the human chromosomes are preferentially lost, and most murine and human forms of homologous isozymes are clearly distinguishable1,2. There are, however, certain limitations in this system which call for the introduction of other interspecific somatic cell hybrids. (1) Not all the enzyme phenotypes of man and mouse are easily distinguishable by conventional electrophoretic procedures. (2) Groups of human chromosomes may be preferentially retained or lost in the man-mouse hybrids3. We do not know whether such groups form regular patterns and are constant for a particular hybrid type. (3) The frequency and types of chromosomal rearrangements, which has been reported in man-mouse hybrids, might be different in other human interspecific hybrids.
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WESTERVELD, A., VISSER, R., KHAN, P. et al. Loss of Human Genetic Markers in Man-Chinese Hamster Somatic Cell Hybrids. Nature New Biology 234, 20–24 (1971). https://doi.org/10.1038/newbio234020a0
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DOI: https://doi.org/10.1038/newbio234020a0
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