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Effect of the Thiol-oxidizing Agent, Diamide, on Acetylcholine Release at the Frog Endplate

Nature New Biology volume 233, pages 120–121 (1971)Cite this article

Abstract

REDUCED glutathione (GHS) is maintained in substantial concentration (3 × 10−3 M) within neurones1. The availability of new thiol-oxidizing agents like diamide2,3, which freely enter cells and the principal action of which is to reduce the GSH concentration by conversion to GSSG (equation 1), promoted an investigation of the effects of these agents on release of transmitter at frog myoneural junctions.

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Author information

Author notes

  1. PETER L. CARLEN

    Present address: Department of Neurology, University of Toronto, Toronto

Authors and Affiliations

  1. Institute of Life Sciences, Hebrew University, Jerusalem

    ROBERT WERMAN, PETER L. CARLEN & MOSHE KUSHNIR

  2. Department of Chemistry, State University of New York, Stony Brook, New York

    EDWARD M. KOSOWER

Authors
  1. ROBERT WERMAN
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  2. PETER L. CARLEN
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  3. MOSHE KUSHNIR
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  4. EDWARD M. KOSOWER
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WERMAN, R., CARLEN, P., KUSHNIR, M. et al. Effect of the Thiol-oxidizing Agent, Diamide, on Acetylcholine Release at the Frog Endplate. Nature New Biology 233, 120–121 (1971). https://doi.org/10.1038/newbio233120a0

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