Adrenal Cortico-medullary Transplant with Antihypertensive Activity in the Rat


THE suspicion that the adrenal gland may possess an antihypertensive function rests on the observation that adrenal cortical extracts have antihypertensive activity in man and oppose hypertension induced by deoxycorticosterone in the rat1,2. We have reasoned that if there is such a function, or a salt-losing role for the adrenal gland3, it is probably localized outside the zona glomerulosa. We have, therefore, carried out a series of transplantation experiments with potential autografts from the medulla and adjacent zona reticularis in the rat. Viable transplants have been produced and appear to have antihypertensive activity.

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  1. 1

    Friedman, S. M., and Friedman, C. L., Endocrinology, 46, 367 (1950).

  2. 2

    Pines, K. L., Perera, G. A., Vislocky, K., and Barrows, A. D., Proc. Soc. Exp. Biol. Med., 68, 286 (1948).

  3. 3

    George, J. M., Saucier, G., and Bartter, F. C., J. Clin. Endocrinol. Metab., 25, 621 (1965).

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FRIEDMAN, S., FRIEDMAN, C. & NAKASHIMA, M. Adrenal Cortico-medullary Transplant with Antihypertensive Activity in the Rat. Nature New Biology 233, 23–25 (1971) doi:10.1038/newbio233023a0

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