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Infection of Tumour Cells by Fowl Plague Virus in the Presence of Actinomycin D

Nature New Biology volume 232, pages 179–181 (1971)Cite this article

Abstract

INFLUENZA virus is one of the few viruses in which replication is inhibited by the antimetabolite actinomycin D (AM-D)1–4, which inhibits DNA-dependent RNA synthesis in mammalian cells5. It has been reported that the growth of fowl plague virus (FPV) in virus-transformed hamster cells is less sensitive to AM-D6,7. We have examined the sensitivity of FPV to AM-D to see whether it is related to differences in the oncogenic properties of tumour cells. We found that in cells transformed by polyoma virus (PV) and also in cells transformed by methylcholanthrene, although no infectious virus was produced the cells synthesized viral haemagglutinin (HA). It was only the cell-associated HA, however, that was affected by AM-D and not that released by the cells.

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Authors and Affiliations

  1. Department of Virology, Royal Postgraduate Medical School, Ducane Road, London, W12

    LIVIO MALLUCCI

  2. National Institute for Medical Research, Mill Hill, London, NW7

    JOHN J. SKEHEL

Authors
  1. LIVIO MALLUCCI
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  2. JOHN J. SKEHEL
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MALLUCCI, L., SKEHEL, J. Infection of Tumour Cells by Fowl Plague Virus in the Presence of Actinomycin D. Nature New Biology 232, 179–181 (1971). https://doi.org/10.1038/newbio232179a0

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