Abstract
RNA-DEPENDENT. DNA polymerase an activity initially thought to be unique to RNA tumour viruses1–3, is now known to be present in normal human lymphocytes4, which are differentiated and seldom divide in vivo or in culture. The addition of phytohaemagglutinin (PHA) or other mitogens (including appropriate antigens) transforms lymphocytes into actively proliferating cells5. Several enzymes which function in gene activation and DNA replication specifically increase in activity during this transformation6,7. We now report that RNA-dependent DNA polymerase also behaves in this way.
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PENNER, P., COHEN, L. & LOEB, L. RNA-dependent DNA Polymerase in Human Lymphocytes during Gene Activation by Phytohaemagglutinin. Nature New Biology 232, 58–61 (1971). https://doi.org/10.1038/newbio232058a0
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DOI: https://doi.org/10.1038/newbio232058a0
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