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Changes induced by Hepatitis Serum in Cultured Liver Cells

Abstract

THE discovery of the relationship between the Australia (hepatitis-associated) antigen and serum hepatitis has provided a specific serological marker of infection for type B viral hepatitis. The precise biological nature of the Australia antigen remains uncertain and so far there has been no convincing demonstration of the successful infection of tissue culture preparations in spite of extensive efforts1. We now report the nuclear involvement of cultured primary human embryo liver cells inoculated with the serum of a well-documented former blood donor (P. J. G.) whose blood had been implicated in the transmission of serum hepatitis in transfused recipients and had induced serum hepatitis in human volunteers. Australia antigen has been repeatedly demonstrated in the serum of this blood donor1,2.

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BRIGHTON, W., TAYLOR, P. & ZUCKERMAN, A. Changes induced by Hepatitis Serum in Cultured Liver Cells. Nature New Biology 232, 57–58 (1971). https://doi.org/10.1038/newbio232057a0

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  • DOI: https://doi.org/10.1038/newbio232057a0

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