Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

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Abstract

Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.

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References

  1. 1

    Collier, H. O. J., Adv. Pharmacol. Chemother., 7, 333 (1969).

  2. 2

    Collier, H. O. J., Nature, 223, 35 (1969).

  3. 3

    Collier, H. O. J., and Shorley, P. G., Brit. J. Pharmacol. Chemother., 15, 601 (1960).

  4. 4

    Collier, H. O. J., and Shorley, P. G., Brit. J. Pharmacol. Chemother., 20, 345 (1963).

  5. 5

    Berry, P. A., and Collier, H. O. J., Brit. J. Pharmacol. Chemother., 23, 201 (1964).

  6. 6

    Collier, H. O. J., James, G. W. L., and Schneider, C., Nature, 212, 411 (1966).

  7. 7

    Jacques, R., Helv. Physiol. Pharmacol. Acta, 23, 156 (1965).

  8. 8

    Berry, P. A., thesis, Council for National Academic Awards, London, 91 (1966).

  9. 9

    Collier, H. O. J., and Sweatman, J. F., Nature, 219, 864 (1968).

  10. 10

    Piper, P. J., and Vane, J. R., Nature, 223, 29 (1969).

  11. 11

    Piper, P. J., and Vane, J. R., in Prostaglandins, Peptides and Amines (edit. by Mantegazza, P., and Horton, E. W.), 15 (Academic Press, London, 1969).

  12. 12

    Vargaftig, B. B., and Dao, N., Pharmacology (in the press).

  13. 13

    Piper, P. J., and Vane, J. R., in Prostaglandins (edit. by Ramwell, P., and Shaw, J.) (NY Acad. Sci., in the press, 1971).

  14. 14

    Ånggård, E., and Samuelsson, B., J. Biol. Chem., 240, 3518 (1965).

  15. 15

    Ferreira, S. H., and Vane, J. R., Nature, 216, 868 (1967).

  16. 16

    Vane, J. R., Brit. J. Pharmacol. Chemother., 12, 344 (1957).

  17. 17

    Regoli, D., and Vane, J. R., Brit. J. Pharmacol. Chemother., 23, 351 (1964).

  18. 18

    Gaddum, J. H., Brit. J. Pharmacol. Chemother., 8, 321 (1953).

  19. 19

    Gilmore, N., Vane, J. R., and Wyllie, J. H., Nature, 218, 1135 (1968).

  20. 20

    Gréen, K., and Samuelsson, B., J. Lipid Res., 5, 117 (1964).

  21. 21

    Willis, A. L., Brit. J. Pharmacol., 40, 583P (1970).

  22. 22

    Milton, A. S., and Wendlandt, S. J., J. Physiol., 207, 76P (1970).

  23. 23

    Feldberg, W., and Saxena, P. N., J. Physiol. (in the press, 1971).

  24. 24

    Willis, A. L., in Prostaglandins, Peptides and Amines (edit. by Mantegazza, P., and Horton, E. W.), 31 (Academic Press, London, 1969).

  25. 25

    Greaves, M. W., Søndergaard, J., and McDonald-Gibson, W., Brit. Med. J., 2, 258 (1911).

  26. 26

    Crunkhorn, P., and Willis, A. L., Brit. J. Pharmacol., 41, 49 (1971).

  27. 27

    Bergström, S., Carlson, L. A., and Weeks, J. R., Pharmacol. Rev., 20, 1 (1968).

  28. 28

    Collier, H. O. J., Nature (in the press).

  29. 29

    James, G. W. L., J. Pharm. Pharmacol., 21, 379 (1969).

  30. 30

    Goodman, L. S., and Gilman, A., The Pharmacological Basis ofTherapeutics, fourth ed. (Collier-Macmillan, London, 1970).

  31. 31

    Hucker, H. B., Zacchei, A. G., Cox, S. V., Brodie, D. A., and Cantwell, N. H. R., J. Pharmac. Exp. Therap., 153, 237 (1966).

  32. 32

    Nugteren, D. H., Beerhuis, R. K., and Van Dorp, D. A., Reel. Trav. Chim. Pays-Bas Belg., 85, 405 (1966).

  33. 33

    Karim, S. M. M., Brit. Med. J., 4, 618 (1968).

  34. 34

    Chaudhuri, G., Lancet, i, 480 (1971).

  35. 35

    Smith, J. B., and Willis, A. L., Nature New Biology, 231, 235 (1971).

  36. 36

    Ferreira, S. H., Moncada, S., and Vane, J. R., Nature New Biology, 231, 237 (1971).

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VANE, J. Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs. Nature New Biology 231, 232–235 (1971) doi:10.1038/newbio231232a0

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