Abstract
TWO explanations have been provided for the relatively long latency and prolonged (often exceeding 100 ms) inhibition of firing of spinal motoneurones which is caused by repetitive impulses produced by electrical or natural stimulation1–4 in muscle and cutaneous afferent fibres. This prolonged inhibitory process is exemplified by the reduction in the amplitude of monosynaptic excitatory synaptic potentials (EPSPs) and reflexes of extensor motoneurones by tetanic stimulation of group I afferents of flexor motoneurones2. In contrast with “direct” inhibition, the prolonged inhibition is not reduced by strychnine but is diminished by Picrotoxin4,6.
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CURTIS, D., FELIX, D. GABA and Prolonged Spinal Inhibition. Nature New Biology 231, 187–188 (1971). https://doi.org/10.1038/newbio231187a0
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DOI: https://doi.org/10.1038/newbio231187a0
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