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Morphological Transformation of Rat Embryo Cells by the Combined Action of 3-Methylcholanthrene and Rauscher Leukaemia Virus

Nature New Biology volume 230, pages 144–146 (1971)Cite this article

Abstract

RAT embryo cells infected with either CF-1 or Rauscher C-type RNA murine leukaemia virus, when treated with diethylnitrosamine (DENA), undergo morphological transformation and become aneuploid1. Untreated cells and cells treated with either virus or chemical alone do not transform. We describe here a similar effect of 3-methylcholanthrene (3 MC) on rat cells infected with Rauscher leukaemia virus.

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References

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Authors and Affiliations

  1. Microbiological Associates Inc., Bethesda, Maryland, 20014

    PAUL J. PRICE & AARON E. FREEMAN

  2. National Institutes of Health, Bethesda, Maryland, 20014

    WILLIAM T. LANE & ROBERT J. HUEBNER

Authors
  1. PAUL J. PRICE
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  2. AARON E. FREEMAN
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  3. WILLIAM T. LANE
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  4. ROBERT J. HUEBNER
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PRICE, P., FREEMAN, A., LANE, W. et al. Morphological Transformation of Rat Embryo Cells by the Combined Action of 3-Methylcholanthrene and Rauscher Leukaemia Virus. Nature New Biology 230, 144–146 (1971). https://doi.org/10.1038/newbio230144a0

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  • DOI: https://doi.org/10.1038/newbio230144a0

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