Abstract
THE energy-dependent accumulation of Ca2+ by isolated rat liver mitochondria is intimately associated with oxidative phosphorylation1. Available evidence supports the idea that, like the permeases postulated for some mitochondrial metabolites2, this active accumulation of Ca2+ may involve a “carrier” in the mitochondrial membrane specific for Ca2+ (ref. 3). Several studies have shown that the energy-independent “binding” of Ca2+ to sites on the (inner membrane of), intact mitochondria and of submitochondrial particles exhibits hyperbolic saturation curves as a function of Ca2+ concentration4, 5.
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BYGRAVE, F., REED, K. & SPENCER, T. Cooperative Interactions in Energy-dependent Accumulation of Ca2+ by Isolated Rat Liver Mitochondria. Nature New Biology 230, 89 (1971). https://doi.org/10.1038/newbio230089a0
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DOI: https://doi.org/10.1038/newbio230089a0
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