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Anomalous Effects of Heterologous Normal Serum on Interferon Production in Mice

Nature New Biology volume 230, pages 17–18 (1971)Cite this article

Abstract

WHILE studying the inhibitory effect of burro anti-mouse lymphocyte serum on the production of interferon in mice1, we investigated whether rabbit anti-mouse lymphocyte serum (ALS) had similar activity. There was some inhibition of interferon production after intraperitoneal injection of polyinosinic/polycytidylic acid (poly IC) in NIH Swiss strain mice pretreated with three doses of potent rabbit anti-mouse lymphocyte serum. Animals treated with normal rabbit serum, however, showed a similar inhibition of interferon production (Table 1), although normal burro serum had no effect1.

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Authors and Affiliations

  1. Laboratory of Pathology, National Cancer Institute,

    ROBERT M. FRIEDMAN & ROLF F. BARTH

  2. Laboratory of Biochemistry, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, 20014

    ROBERT STERN

Authors
  1. ROBERT M. FRIEDMAN
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  2. ROLF F. BARTH
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  3. ROBERT STERN
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FRIEDMAN, R., BARTH, R. & STERN, R. Anomalous Effects of Heterologous Normal Serum on Interferon Production in Mice. Nature New Biology 230, 17–18 (1971). https://doi.org/10.1038/newbio230017a0

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