Anomalous Effects of Heterologous Normal Serum on Interferon Production in Mice

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WHILE studying the inhibitory effect of burro anti-mouse lymphocyte serum on the production of interferon in mice1, we investigated whether rabbit anti-mouse lymphocyte serum (ALS) had similar activity. There was some inhibition of interferon production after intraperitoneal injection of polyinosinic/polycytidylic acid (poly IC) in NIH Swiss strain mice pretreated with three doses of potent rabbit anti-mouse lymphocyte serum. Animals treated with normal rabbit serum, however, showed a similar inhibition of interferon production (Table 1), although normal burro serum had no effect1.

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  1. 1

    Barth, R. F., Friedman, R. M., and Malmgren, R. A., Lancet, ii, 723 (1969).

  2. 2

    Baron, S., Buckler, C. E., Levy, H. B., and Friedman, R. M., Proc. Soc. Exp. Biol. Med., 125, 1320 (1967).

  3. 3

    Stern, R., Fed. Proc., 29, 933 (1970).

  4. 4

    Robertson, H. D., Webster, R. E., and Zinder, N. D., Virology, 32, 718 (1967).

  5. 5

    Libonati, M., and Floridi, A., Europ. J. Biochem., 8, 81 (1969).

  6. 6

    Finter, N. B., J. Gen. Virol., 5, 419 (1969).

  7. 7

    Sheagren, J. N., Barth, R. F., Edelin, J. B., and Malmgren, R. A., J. Immunol., (in the press).

  8. 8

    Friedman, R. M., and Cooper, H. L., Proc. Soc. Exp. Biol. Med., 125, 901 (1967).

  9. 9

    Green, J. A., Cooperband, S. R., and Kibrick, S., Science, 164, 1415 (1969).

  10. 10

    Haar, S., Acta Pathol. Microbiol. Scand., 77, 167 (1969).

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FRIEDMAN, R., BARTH, R. & STERN, R. Anomalous Effects of Heterologous Normal Serum on Interferon Production in Mice. Nature New Biology 230, 17–18 (1971) doi:10.1038/newbio230017a0

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