Abstract
Physico-chemical experiments show that histones are not evenly distributed in chromatin. About half of the DNA is “open” and not covered with proteins.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Skalka, A., Fowler, A. V., and Hurwitz, J., J. Biol. Chem., 241, 588 (1966).
Paul, J., and Gilmour, R. S., J. Mol. Biol., 16, 242 (1966). Gilmour, R. S., and Paul, J., ibid., 40, 137 (1969).
Marushige, K., and Bonner, J., J. Mol. Biol., 15, 160 (1966).
Bonner, J., and Huang, R. C., J. Mol. Biol., 6, 169 (1963).
Melli, M., and Bishop, J. O., J. Mol. Biol., 40, 117 (1969).
Smith, K. D., Church, R. B., and McCarthy, B. J., Biochemistry, 8, 4271 (1969).
Tan, C. H., and Miyagi, M., J. Mol. Biol., 50, 641 (1970).
Kurashina, Y., Ohba, Y., and Mizuno, D., J. Biochemistry, 67, 661 (1970).
Shih, T. Y., and Bonner, J., J. Mol. Biol., 48, 469 (1970).
Vendrely, R., Knobloch-Mazen, A., and Vendrely, C., Biochem. Pharm., 4, 19 (1960).
Erdmann, V. A., Thomas, G. A., Norton, J. W., and Herbst, E. J., Biochim. Biophys. Acta, 157, 43 (1968).
Sober, H. A., Schlossman, S., Yaron, A., Latt, S. A., and Rushizky, G. W., Biochemistry, 5, 3608 (1966).
Murray, K., J. Mol. Biol., 39, 628 (1969).
Studier, W. F., J. Mol. Biol., 11, 373 (1965).
Hirschman, S. Z., and Felsenfeld, G., J. Mol. Biol., 16, 347 (1966).
Britten, R. J., and Kohne, D. E., Science, 161, 529 (1968).
Akinrimisi, E. O., Bonner, J., and Ts'o, P. O. P., J. Mol. Biol., 11, 128 (1965). Tsuboi, M., Matsuo, K., and Ts'o, P. O. P., ibid., 15, 256 (1966).
Alberts, B. M., Amodio, F. J., Jenkins, M., Gutmann, E. D., and Ferris, F. L., Cold Spring Harbor. Symp. Quant. Biol., 33, 289 (1969).
Jensen, R. H., and Chalkley, R., Biochemistry, 7, 4388 (1968).
Doppler-Bernardi, F., and Felsenfeld, G., Biopolymers, 8, 733 (1969).
Ohba, Y., Biochim. Biophys. Acta, 123, 76 (1966).
Faulhaber, I., and Bernardi, G., Biochim. Biophys. Acta, 140, 437 (1968).
Henson, P., and Walker, I. O., Eur. J. Biochem., 14, 345 (1970).
Klein, F., and Szirmai, J. A., Biochim. Biophys. Acta, 72, 48 (1963).
Miura, A., and Ohba, Y., Biochim. Biophys. Acta, 145, 436 (1967).
Bustin, M., Rail, S. C., Stellwagen, R. H., and Cole, R. D., Science, 163, 391 (1969). DeLange, R. J., Fambrough, D. M., Smith, E. L., and Bonner, J., J. Biol. Chem., 244, 319 (1969).
Georgiev, G. P., and Ilyin, Y. V., J. Mol. Biol., 41, 299 (1969).
Paul, J., and Gilmour, R. S., J. Mol. Biol., 34, 305 (1968).
Burgess, R. R., Travers, A. A., Dunn, J. J., and Bautz, E. K. F., Nature, 221, 43 (1969).
Bautz, E. K. F., and Bautz, F. A., Nature, 226, 1219 (1970).
Chauveau, J., Moule, Y., and Rouiller, Ch., Exp. Cell Res., 11, 317 (1956).
Lowry, O. H., Rosebrough, N. J., Fair, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).
Dingman, C. W., and Sporn, M. B., J. Biol. Chem., 239, 3483 (1964).
Purkayastha, R., and Neelin, J. M., Biochim. Biophys. Acta, 117, 468 (1966).
Sanger, F., and Thompson, E. O. P., Biochem. J., 53, 353 (1953).
Itzhaki, R., Biochem. Biophys. Res. Commun., 41, 25 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CLARK, R., FELSENFELD, G. Structure of Chromatin. Nature New Biology 229, 101–106 (1971). https://doi.org/10.1038/newbio229101a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/newbio229101a0
This article is cited by
-
Cell-type-specific chromatin occupancy by the pioneer factor Zelda drives key developmental transitions in Drosophila
Nature Communications (2021)
-
Chromatin history: our view from the bridge
Nature Reviews Molecular Cell Biology (2003)