Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Polymerization of Tobacco Mosaic Virus Protein and its Control

Abstract

Near neutral pH9 TMV protein sub-units polymerize into two-layer aggregates culminating in the 20S disk, whereas the helical rod forms cooperatively at acid pH. The mode of aggregation is controlled by the state of ionization of two abnormally titrating carboxyl groups.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Durham, A. C. H., Finch, J. T., and Klug, A., Nature New Biology, 229, (1971).

  2. Butler, P. J. G., and Klug, A., Nature New Biology, 229, 47 (1971).

    Article  CAS  Google Scholar 

  3. Caspar, D. L. D., Adv. Prot. Chem., 18, 37 (1963).

    CAS  Google Scholar 

  4. Durham, A. C. H., thesis, Univ. Cambridge (1970).

  5. Banerjee, K., and Lauffer, M. A., Biochemistry, 5, 1957 (1966).

    Article  CAS  Google Scholar 

  6. Eiskamp, J. G., thesis, Univ. Oregon (1969).

  7. Lauffer, M. A., and Stevens, C. L., Adv. Virus Research, 13, 1 (1968).

    Article  CAS  Google Scholar 

  8. Ansevin, A. T., Stevens, C. L., and Lauffer, M. A., Biochemistry, 3, 1512 (1964).

    Article  CAS  Google Scholar 

  9. Scheele, R. B., and Lauffer, M. A., Biochemistry, 6, 3076 (1967).

    Article  CAS  Google Scholar 

  10. Ansevin, A. T., and Lauffer, M. A., Biophys. J., 3, 239 (1963).

    Article  CAS  Google Scholar 

  11. Atabekov, J. G., Novikov, V. K., Kiselev, N. A., Kaftanova, A. S., and Egorov, A. M., Virology, 36, 620 (1968).

    Article  CAS  Google Scholar 

  12. Semancik, J. S., and Reynolds, D. A., Science, 164, 559 (1969).

    Article  CAS  Google Scholar 

  13. Hitchborn, J. H., and Hills, G. J., Virology, 27, 528 (1965).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

DURHAM, A., KLUG, A. Polymerization of Tobacco Mosaic Virus Protein and its Control. Nature New Biology 229, 42–46 (1971). https://doi.org/10.1038/newbio229042a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio229042a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing