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Concentration of Cyclic Adenosine 3′,5′ -Monophosphate in Human Leucocytes during Phagocytosis

Nature New Biology volume 229, pages 27–29 (1971)Cite this article

Abstract

CYCLIC adenosine 3′,5′-monophosphate (cyclic AMP) has been established as a mediator of various hormonal effects in the appropriate target cells1. Adenyl cyclase converts adenosine triphosphate (ATP) to cyclic AMP and is widely distributed in the membrane of mammalian nucleated cells2–4. Since the early process of phagocytosis involves the physical and chemical contact of the cell membrane to the objects and subsequent formation of phagosome, we postulated that one of the earliest biochemical changes during phagocytosis might be an activation of adenyl cyclase and an alteration of concentrations of cyclic AMP in the phagocytes.

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Authors and Affiliations

  1. Department of Pathology and Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, 55455

    B. H. PARK & R. A. GOOD

  2. Department of Internal Medicine, University of Pittsburgh Medical School, Pennsylvania

    N. P. BECK & P. B. DAVIS

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  1. B. H. PARK
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  2. R. A. GOOD
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  3. N. P. BECK
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  4. P. B. DAVIS
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PARK, B., GOOD, R., BECK, N. et al. Concentration of Cyclic Adenosine 3′,5′ -Monophosphate in Human Leucocytes during Phagocytosis. Nature New Biology 229, 27–29 (1971). https://doi.org/10.1038/newbio229027a0

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  • DOI: https://doi.org/10.1038/newbio229027a0

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