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Incorporating fluorescence cystoscopy for the diagnosis of bladder cancer into clinical practice

Nature Clinical Practice Urology volume 5, pages 424–425 (2008)Cite this article

In the Western World, transitional cell carcinoma (TCC) of the bladder represents the fourth most frequently diagnosed malignancy,1 and in 2008 an estimated 68,810 new incidences of TCC of the bladder will be diagnosed in the US.2 Of the patients newly diagnosed with bladder cancer, approximately 80% present with a non-muscle-invasive tumor.3 A wide range of recurrence and progression rates exists in patients with bladder cancer, and these rates depend largely on the number of tumors initially identified, tumor size, prior recurrence rate, T category, tumor grade and concomitant carcinoma in situ (CIS). According to data from the European Organisation for Research and Treatment of Cancer (EORTC), the probability of recurrence at 5 years after diagnosis is 31–78%, and the probability of disease progression at 5 years is <1%–45%.4 These high recurrence and progression rates have resulted in long-term surveillance and therapy for patients with bladder cancer, making TCC of the bladder the fifth most expensive cancer in terms of total medical care expenditures (almost $3.7 billion in 2001 in the US).5

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Acknowledgements

We thank Dr Herbert Stepp who had a great role in the development of the currently used fluorescence endoscopy technology.

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Authors and Affiliations

  1. and CG Stief is a Professor and Chairman of the Department of Urology, A Karl is a Post-Graduate Year 5 Urology Resident, D Zaak is an Associate Professor, Ludwig-Maximilians-University, Munich, Germany.,

    Alexander Karl, Dirk Zaak & Christian G Stief

  2. A Karl is also currently working as an Oncology Research Fellow at the University of California at San Francisco, San Francisco, CA, USA.,

    Alexander Karl

Authors
  1. Alexander Karl
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  2. Dirk Zaak
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  3. Christian G Stief
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Correspondence to Alexander Karl.

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Competing interests

A Karl and D Zaak have acted as investigators on a study supported by Photocure, and have received honoraria from GE Medical and Photocure. D Zaak has also received honoraria from medac GmbH. CG Stief declared no competing interests.

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Karl, A., Zaak, D. & Stief, C. Incorporating fluorescence cystoscopy for the diagnosis of bladder cancer into clinical practice. Nat Rev Urol 5, 424–425 (2008). https://doi.org/10.1038/ncpuro1150

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